Interfaces Between Alpha-helical Integral Membrane Proteins: Characterization, Prediction, and Docking
نویسندگان
چکیده
منابع مشابه
Prediction of buried helices in multispan alpha helical membrane proteins.
Analysis of a database of structures of membrane proteins shows that membrane proteins composed of 10 or more transmembrane (TM) helices often contain buried helices that are inaccessible to phospholipids. We introduce a method for identifying TM helices that are least phospholipid accessible and for prediction of fully buried TM helices in membrane proteins from sequence information alone. Our...
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Integral membrane proteins play a vital role in a number of essential biological functions. Although abundant, about 30% of genes are known to code for membrane proteins, the number of solved structures in the pdb is less than 1%. Thus, structure prediction of membrane proteins is an essential tool for understanding their functions. A fundamental characteristic of the predicted structure is the...
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The prediction of transmembrane helical segments (TMHs) in membrane proteins is an important field in the bioinformatics research. In this paper, a method based on discrete wavelet transform (DWT) has been developed to predict the number and location of TMHs in membrane proteins. PDB coded as 1F88 was chosen as an example to describe the prediction of the number and location of TMHs in membrane...
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ژورنال
عنوان ژورنال: Computational and Structural Biotechnology Journal
سال: 2019
ISSN: 2001-0370
DOI: 10.1016/j.csbj.2019.05.005